Many people with moderate or severe pulmonary sarcoidosis — the target market for the investigational therapy efzofitimod — are highly burdened by the disease and are dependent on corticosteroids that can have serious side effects, according to real-world analyses. “New real-world evidence underscores the growing burden of patients…
The National Organization for Rare Disorders (NORD) is seeking participants for its survey-based study Living Rare, which aims to better understand the real-world lived experiences of people in the U.S. with rare diseases. Living Rare, the first large-scale study of its kind in the U.S., seeks to capture the…
Autoimmune responses against healthy proteins in the retina, which is the back of the eye, could play a role in driving a type of eye inflammation called uveitis in people with ocular sarcoidosis, per a new study. According to the researchers, self-reactive antibodies against the retina were found more…
The Foundation for Sarcoidosis Research (FSR) has granted $300,000 in funding to support three scientists embarking on research studies that could lead to advancements in the diagnosis or treatment of sarcoidosis, or in patient care. Each of the three researchers was awarded $100,000 through the FSR’s Pilot…
Among cardiac sarcoidosis (CS) patients treated with immunosuppressants, those with heart involvement alone can have poorer clinical outcomes than those whose sarcoidosis affects other organs along with the heart, according to a small study. Despite showing less heart inflammation before starting treatment, people with isolated CS (iCS) experienced higher…
Among people with sarcoidosis who failed to respond to earlier lines of treatment, the use of abatacept or tofacitinib — medications approved for other inflammatory conditions — appeared safe and effective, according to a Danish report. While neither abatacept (sold as Orencia in the U.S. and Europe) nor…
The activation of signaling pathways associated with immune B-cells may be a key feature that distinguishes sarcoidosis from tuberculosis, according to new research. Both conditions are characterized by the presence of granulomas, or small clumps of inflammatory cells, and can have similar clinical manifestations, such as uveitis, a type…
Involvement of the pericardium, a sac-like membrane that surrounds and protects the heart, is an uncommon manifestation of cardiac sarcoidosis that doctors should consider when there’s evidence of heart inflammation, a case report suggests about a woman who reported chest pain during a visit to a clinic. “This case…
High blood calcium levels, or hypercalcemia, may in rare cases be a symptom of sarcoidosis, according to a case report from Morocco. Steroid medications helped ease the symptom for a man with severe hypercalcemia as a main complication of sarcoidosis of the lungs, or pulmonary sarcoidosis, according to…
Being Black or having restrictive lung disease, where it’s hard to take in enough air in a breath, were factors that predicted faster lung function declines in people with pulmonary sarcoidosis in a recent U.S. study. “This study can inform future prospective studies to further explore pulmonary function phenotypes…
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