Marisa Wexler, MS,  senior science writer—

More than two dozen mutations that seem to increase the risk of developing sarcoidosis were identified in a new study. Notably, 17 of the 28 mutations hadn’t been linked to the inflammatory disease. Higher genetically predicted body mass index (BMI) and higher levels of several proteins involved in inflammation…

The findings of a new preclinical study in pulmonary sarcoidosis are lending support to the therapeutic potential of efzofitimod, a treatment candidate from Atyr Pharma now being tested in a Phase 3 clinical trial. The researchers found that a protein called HARS-WHEP — whose activity is mimicked by…

The U.S. Food and Drug Administration (FDA) has approved a prefilled syringe version of purified Cortrophin Gel (repository corticotropin injection) as an add-on treatment for people with symptoms of sarcoidosis. Sold by Ani Pharmaceuticals, the original vial format of Corticotrophin Gel received FDA clearance in 2021 to treat…

Roivant Sciences is planning to launch a Phase 2 clinical trial this year to test its experimental oral therapy brepocitinib in adults with cutaneous sarcoidosis. The company said it expects to start the trial between April and June, and that the study’s results should become available in the…

Kinevant Sciences’ experimental therapy namilumab failed to show a benefit for people with chronic, active pulmonary sarcoidosis in a Phase 2 clinical trial involving more than 100 patients. Based on the negative results of the RESOLVE-Lung study (NCT05314517), the company announced it will be discontinuing further development…

People with sarcoidosis in the U.S. are more likely than those in the general population to have certain co-occurring autoimmune disorders, including lupus and multiple sclerosis (MS). That’s according to “Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program,” which…

The lungs are affected in nearly everyone diagnosed with sarcoidosis in the Netherlands, but most patients in the country don’t have disease severe enough to warrant systemic immune-suppressing treatments at the time of diagnosis. That’s according to the findings of a new study, “Organ involvement in…

Treatment with Remicade (infliximab) is generally effective for controlling sarcoidosis when it affects the nervous system or liver, but patients whose disease affects the skin or skeletal system aren’t as likely to respond to it, a study reports. “[Remicade] shows promise for treating patients with sarcoidosis, particularly with…

A test that detects disease-specific antibodies in the blood could help to diagnose sarcoidosis more quickly and easily, according to a recent study. “More testing needs to be completed before this screening method is ready for clinical use, but it’s possible that could be a reality within a few…

Acthar Gel (repository corticotropin injection) treats African Americans with sarcoidosis as effectively as it does patients of other races, a study suggests. The study, “Acthar Gel in African Americans versus Non-African Americans with Symptomatic Sarcoidosis: Physician Assessment of Patient Medical Records,” was published in Therapeutics…