Researchers at the University of Washington in Seattle identified numerous gene pathways that are altered in sarcoidosis, not only confirming the involvement of the innate immune system, but also demonstrating that systems for protein breakdown are activated in the disease. The study, “Sarcoidosis activates diverse transcriptional…

Relief Therapeutics, readying for a pivotal clinical trial of a sarcoidosis treatment, announced that it is acquiring FirstString Research in an all-stock transaction that will add an advanced clinical stage product, Granexin, a potential treatment for diabetic foot ulcers and venous leg ulcers, to its drug portfolio. Relief will  also acquire FirstString’s pipeline…

Researchers at Jichi Medical University in Japan reported a case of sarcoidosis relapse in a woman who developed renal dysfunction, high calcium levels, as well as kidney and urethral stones. The report, “Renal Failure Found during the Follow-up of Sarcoidosis: The Relevance of a Delay in…

Analyzing the bronchoalveolar lavage fluid (called BALF, it is a small sample of the fluid present in the lungs) for the ratio of immune CD4 and CD8 cells may improve the diagnosis of sarcoidosis, according to the results of a recent study. BALF is collected through a medical procedure using a bronchoscope that is…

Weight loss and digestive symptoms such as nausea, vomiting, diarrhea, and digestive bleeding could be linked to digestive tract sarcoidosis (DTS), especially in patients of African and Afro-Caribbean origin, according to a study conducted by French researchers.

Verrucous sarcoidosis, a rare form of skin sarcoidosis, may be associated with human papillomavirus (HPV) infection, researchers in Fort Lauterdale, Florida, and colleagues document for the first time in a case study. Their study, “Verrucous sarcoidosis associated with human papillomavirus infection: A case report,” published in…

For patients with sarcoidosis, high levels of inflammatory markers may predict systemic hypertension (sHTN), high blood pressure in the systemic arteries that carry blood from the heart to the body’s tissues — but little was known about the relationship, until recently. The study, “The Association between ESR and CRP and Systemic Hypertension…

There may be an association between the level of inflammation in sarcoidosis patients and their risk of developing pulmonary hypertension (PH), according to a new study.

Sarcoidosis is often detected through the identification of specific characteristics on high-resolution computed tomography (HRCT). But some rare manifestations of the disease may easily lead to misdiagnosis for other conditions. Researchers at the First Affiliated Hospital of Dalian Medical University in China recently presented the case of a patient who exhibited an…

Japanese researchers described a rare case study of neurosarcoidosis affecting only the central nervous system then concluded that while the condition is easy to treat, its diagnosis is difficult. The case report, “Isolated neurosarcoidosis presenting with multiple cranial nerve palsies,“ published in the journal Surgical…