A woman who underwent a heart transplant for cardiac sarcoidosis later showed signs of sarcoidosis in the brain, a condition known as neurosarcoidosis, highlighting the need for better protocols to monitor and treat sarcoidosis patients after a transplant, scientists report. Immunosuppressive treatments helped to ease the woman’s neurological…
Nearly a quarter of sarcoidosis patients were found to have clinically silent cardiac involvement, in which standard heart symptoms are not observed, recent research indicated. Readily available cardiac screening tools, when used in combination, may help to rule out the presence of this hidden disease manifestation and avoid…
The percentage of natural killer (NK) immune cells in the airways were predictive of a more advanced stage of lung damage and multi-organ involvement in people with pulmonary sarcoidosis, according to a recent report. Altogether, the scientists believe these cells could be “a good prognostic marker” of a more…
Acthar Gel (repository corticotropin injection) may be a cost-effective approach relative to standard-of-care glucocorticoid therapy for adults with advanced active pulmonary sarcoidosis. That’s according to an analysis done by the therapy’s developer Mallinckrodt Pharmaceuticals, which found that “the initial high cost of Acthar Gel treatment for sarcoidosis…
The European Medicines Agency (EMA) has granted XTMAB-16, Xentria‘s investigational antibody therapy, orphan drug designation for sarcoidosis. The status is intended to help speed the development of therapies that would fulfill an unmet health need for people with life-threatening or chronically debilitating rare diseases, which are defined as…
EFZO-FIT, a Phase 3 trial that’s testing treatment candidate efzofitimod in people with pulmonary sarcoidosis, is continuing  following a pre-planned interim safety review, with enrollment expected to finish in the first half of 2024. A data safety and monitoring board (DSMB) examined the trial’s available safety and tolerability…
Workplace exposure to silica, mold/mildew, and pesticides were associated with an increased risk of pulmonary sarcoidosis in a recent review study. By analyzing data from dozens of published studies, scientists identified more than 80 different airborne factors that have been linked to the disease in at least one study.
Treatment with tumor necrosis factor-alpha (TNF-a) inhibitors — which block a type of immune protein in the body — was found to ease signs of inflammation and reduce the need for corticosteroids in people with cardiac sarcoidosis in a new analysis. Safety data, meanwhile, indicated that such treatments were…
Top-line data from an ongoing Phase 2 trial testing Kinevant Sciences’ experimental therapy namilumab in adults with pulmonary sarcoidosis are expected in the second half of 2024. That’s according to a business update from Roivant Sciences, the parent company to Kinevant. Called RESOLVE-Lung (NCT05314517), the…
The U.S. Food and Drug Administration (FDA) has greenlit a month-old request by Molecure to begin a Phase 2 clinical trial of its investigational oral therapy OATD-01 in people with pulmonary sarcoidosis. The proof-of-concept study, which is ready to launch, according to Molecure, will be the first…
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