Half a year has gone by since disgraced pharma executive Martin Shkreli was sentenced to seven years in federal prison for securities and wire fraud while heading San Diego-based Retrophin. As founder and CEO of another company (then known as Turing Pharmaceuticals), in late 2015 Shkreli bought the rights…
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A 49-year-old woman in Australia was simultaneously diagnosed with a rare case of cutaneous sarcoidosis and recurrent metastatic breast cancer, according to a case report. The study “Concurrent diagnoses of cutaneous sarcoidosis and recurrent metastatic breast cancer: more than a coincidental occurrence?” was published in the journal…
aTyr Pharma, which developing therapies to modulate immune pathways involved in lung diseases, has announced an upcoming Phase 1b/2a study to test their lead therapy ATYR1923 in patients with pulmonary sarcoidosis. ATYR1923 is an immunomodulatory molecule that’s able to bind to the Neuropilin-2 (NRP-2) receptor protein, part of…
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Sarcoidosis Patients More Likely to Develop Heart Rhythm Disorders, Large Retrospective Study Finds
Patients with sarcoidosis are more likely to have heart rhythm disorders, specifically ventricular tachycardia, and experience cardiac arrest, a review of a large sample of inpatients in the United States found. Greater rates of heart complications in sarcoidosis patients may…
More than 700 medical experts, pharmaceutical executives, patient advocates, and others are expected to converge on Washington, D.C., next month for the 2018 NORD Rare Diseases & Orphan Products Breakthrough Summit. The Oct. 15-16 event, sponsored by the National Organization for Rare Diseases (NORD), takes place at the…
A new case report describes a patient with arthritis of the sternoclavicular joint (SC joint, the joint between the collar bone and the breastbone, or sternum) who was later diagnosed with sarcoidosis. This kind of arthritis has apparently never been reported before in a sarcoidosis patient. According to the…
Measuring the serum levels of four specific biomarkers could help doctors detect cardiac sarcoidosis, identify patients with systemic lesions instead of heart symptoms only, and predict prognosis, a new study has concluded. The biomarkers are BNP, ACE, sIL-2R and cTnI. The study, “A Multiple Biomarker Approach in Patients…
A potent signaling molecule called interleukin-33, or IL-33, can restore the balance and function of regulatory immune T-cells in mice with pulmonary sarcoidosis, a study showed. The finding suggests that IL-33 may become an important target in preventing the immune-mediated inflammatory processes of pulmonary sarcoidosis. The study, “…
The number of patients diagnosed with sarcoidosis increased in the last decade in Korea, and women in their 50s and 60s were found to be at higher risk, a Korean study shows. The findings were reported in the Respiratory Research journal in the study “Prevalence and incidence of…
Measuring the serum levels of the proteins ACE, YKL-40, CRP, and sIL-2R may enable clinicians to monitor disease activity in sarcoidosis patients, according to researchers from Turkey. Their study, “YKL-40, Soluble IL-2 Receptor, Angiotensin Converting Enzyme and C-Reactive Protein: Comparison of Markers of Sarcoidosis Activity,” was published in…
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