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Sarcoidosis patients appear to have unusual energy production and transmethylation of proteins, as well as an abnormal gut microbiota, according to researchers at Wayne State University School of Medicine and colleagues, who compared the metabolites found in sarcoidosis patients with those of healthy people. The study, “Metabolomics connects aberrant bioenergetic, transmethylation,…

Cancer immunotherapy with Opdivo (nivolumab) and Yervoy (ipilimumab) may or may not trigger sarcoidosis in rare cases, a report from Yale University School of Medicine shows. The study, “Immune-related sarcoidosis observed in combination ipilimumab and nivolumab therapy,” published in the Journal of the American Academy of…

The study “Immunological Evidence for the Role of Mycobacteria in Sarcoidosis: A Meta-Analysis,” published recently in PLOS One, links some patients with sarcoidosis to the development of the disease and the presence of mycobacterium tuberculosis, which causes tuberculosis. Mycobacterium tuberculosis is the second leading cause of death by infectious disease, preceded only…

Psoriasiform lesions are a rare but established manifestation of sarcoidosis, in which psoriasis plaques are formed within sarcoidosis skin lesions. In a recent study, researchers at Thomas Jefferson University in Philadelphia and the University of Miami in Florida presented a case report of a patient with psoriasiform sarcoidosis, and discussed the…

Researchers at the University of Washington in Seattle identified numerous gene pathways that are altered in sarcoidosis, not only confirming the involvement of the innate immune system, but also demonstrating that systems for protein breakdown are activated in the disease. The study, “Sarcoidosis activates diverse transcriptional…

Relief Therapeutics, readying for a pivotal clinical trial of a sarcoidosis treatment, announced that it is acquiring FirstString Research in an all-stock transaction that will add an advanced clinical stage product, Granexin, a potential treatment for diabetic foot ulcers and venous leg ulcers, to its drug portfolio. Relief will  also acquire FirstString’s pipeline…

Researchers at Jichi Medical University in Japan reported a case of sarcoidosis relapse in a woman who developed renal dysfunction, high calcium levels, as well as kidney and urethral stones. The report, “Renal Failure Found during the Follow-up of Sarcoidosis: The Relevance of a Delay in…

Analyzing the bronchoalveolar lavage fluid (called BALF, it is a small sample of the fluid present in the lungs) for the ratio of immune CD4 and CD8 cells may improve the diagnosis of sarcoidosis, according to the results of a recent study. BALF is collected through a medical procedure using a bronchoscope that is…

Weight loss and digestive symptoms such as nausea, vomiting, diarrhea, and digestive bleeding could be linked to digestive tract sarcoidosis (DTS), especially in patients of African and Afro-Caribbean origin, according to a study conducted by French researchers.

Verrucous sarcoidosis, a rare form of skin sarcoidosis, may be associated with human papillomavirus (HPV) infection, researchers in Fort Lauterdale, Florida, and colleagues document for the first time in a case study. Their study, “Verrucous sarcoidosis associated with human papillomavirus infection: A case report,” published in…