aTyr Pharma, which developing therapies to modulate immune pathways involved in lung diseases, has announced an upcoming Phase 1b/2a study to test their lead therapy ATYR1923 in patients with pulmonary sarcoidosis. ATYR1923 is an immunomodulatory molecule that’s able to bind to the Neuropilin-2 (NRP-2) receptor protein, part of…

Patients with sarcoidosis are more likely to have heart rhythm disorders, specifically ventricular tachycardia, and experience cardiac arrest, a review of a large sample of inpatients in the United States found. Greater rates of heart complications in sarcoidosis patients may…

A new case report describes a patient with arthritis of the sternoclavicular joint (SC joint, the joint between the collar bone and the breastbone, or sternum) who was later diagnosed with sarcoidosis. This kind of arthritis has apparently never been reported before in a sarcoidosis patient. According to the…

Measuring the serum levels of four specific biomarkers could help doctors detect cardiac sarcoidosis, identify patients with systemic lesions instead of heart symptoms only, and predict prognosis, a new study has concluded. The biomarkers are BNP, ACE, sIL-2R and cTnI. The study, “A Multiple Biomarker Approach in Patients…

A potent signaling molecule called interleukin-33, or IL-33, can restore the balance and function of regulatory immune T-cells in mice with pulmonary sarcoidosis, a study showed. The finding suggests that IL-33 may become an important target in preventing the immune-mediated inflammatory processes of pulmonary sarcoidosis. The study, “…

The number of patients diagnosed with sarcoidosis increased in the last decade in Korea, and women in their 50s and 60s were found to be at higher risk, a Korean study shows. The findings were reported in the Respiratory Research journal in the study “Prevalence and incidence of…

Measuring the serum levels of the proteins ACE, YKL-40, CRP, and sIL-2R may enable clinicians to monitor disease activity in sarcoidosis patients, according to researchers from Turkey. Their study, “YKL-40, Soluble IL-2 Receptor, Angiotensin Converting Enzyme and C-Reactive Protein: Comparison of Markers of Sarcoidosis Activity,” was published in…

Excessive daytime sleepiness is about twice as frequent in patients with sarcoidosis than in the general population, according to researchers from Germany. The study, “Daytime sleepiness in patients diagnosed with sarcoidosis compared with the general population,” conducted by a team from the University of Leipzig and the Magdeburg-Stendal University…

Older patients tend to show fewer symptoms and abnormal lab results typically associated with ocular sarcoidosis than younger patients, making diagnosis more difficult, a study has found. These findings highlight the need for more studies to explore and find other types of symptoms that could assist with disease diagnosis…

Elderly-onset sarcoidosis patients have different disease and diagnostic features compared to younger-onset patients, researchers from Turkey have found. Sarcoidosis is often diagnosed in young patients between the ages of 25 and 40.  But 30% of the cases are usually diagnosed in older individuals. So there are two forms of the…