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Overactive immune genes may fuel sarcoidosis inflammation: Study

Sarcoidosis appears to involve activation of several immune pathways, particularly those guiding responses against some common viruses. These are the findings of a study that looked for immune signatures of the disease by analyzing differences in gene activity between people with sarcoidosis and healthy controls. “These findings support the…

Rituximab treatment may help some neurosarcoidosis patients

Treatment with rituximab can lead to meaningful improvements for some people with neurosarcoidosis affecting the brain and/or spinal cord — particularly those with hard-to-treat disease and involvement limited to some nerves. That’s according to a retrospective study of 19 people treated across four U.S. centers, which showed that…

Efzofitimod misses main goal in large pulmonary sarcoidosis trial

EFZO-FIT, a Phase 3 clinical study testing efzofitimod for pulmonary sarcoidosis, failed to meet its main goal of significantly reducing the need for corticosteroids among people with the rare inflammatory disease. However, the first-in-class immunomodulatory therapy did show some clinical benefits, according to its developer Atyr Pharma. Specifically,…

4 blood markers may predict outcomes in pulmonary sarcoidosis

Four blood metabolites, or intermediate or end products of the body’s metabolism, could serve as noninvasive biomarkers to monitor or predict disease outcomes in people with pulmonary sarcoidosis — in which the lungs are primarily affected by this rare inflammatory disease — according to the results of a new study…