Steve Bryson, PhD, science writer —

aTyr Pharma is launching a Phase 3 clinical trial to evaluate the safety and effectiveness of efzofitimod (ATYR1923) in people with pulmonary sarcoidosis. Expected to begin later this year, the primary goal of the study — dubbed EFZO-FIT — will be a reduction in therapeutic corticosteroids, which…

The risks of death and rejection after heart transplant for people with advanced cardiac sarcoidosis were similar to those of patients who had transplants for other types of heart disease, according to an analysis of a transplant recipient registry. These findings suggest that a heart transplant is a safe…

A protein called neurofilament light chain (NFL), which supports nerve fibers, is elevated in adults with neurosarcoidosis — and appears to increase with more extensive brain inflammation — a study demonstrated. These findings support the neurofilament protein as a biomarker for disease activity in neurosarcoidosis, a form of…

A rare case of sarcoidosis affecting only the spleen was successfully diagnosed using tissue analysis, after imaging scans and lab tests failed, a case study reported. Sarcoidosis should be considered when multiple tumors in the spleen have been detected, the scientists recommended.  The…

A professor at Northwestern University has been awarded a $50,000 American Thoracic Society (ATS)/Mallinckrodt Pharmaceuticals Research Grant to study the role of immune macrophages in the development of sarcoidosis. Sarcoidosis is a complex immune disease characterized by the accumulation of immune cells such as macrophages,…

Three months of treatment with the common, generic antibiotic azithromycin safely reduced the number of coughs and cough severity, and improved the quality of life in adults with pulmonary sarcoidosis, a small, exploratory study concluded.  The findings…

People with coexisting sarcoidosis and inflammatory bowel disease (IBD) have higher in-hospital rates of respiratory failure, but lower colon surgery rates and gut penetrating disease, than those with IBD alone, a large-scale patient record analysis found. …

A large-scale analysis of proteins in bronchoalveolar lavage cells and fluid isolated from the lungs of people with sarcoidosis identified several different biological pathways not found in healthy individuals, a study reports. The findings may help discover unknown disease mechanisms underlying the…

Mycophenolate mofetil (MMF) significantly reduced disease symptoms in people with sarcoidosis, and helped to reduce their daily dose of corticosteroids, a small study suggests. The study, “Mycophenolate mofetil as an alternative treatment in sarcoidosis,” was published in the…

Sarcoidosis patients and their partners experience a lower quality of life because of nonspecific disease-associated symptoms compared to healthy people, a new study demonstrated.  The study, titled “Quality of Life of Couples Living with Sarcoidosis,” was published in the…