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Treatment with tumor necrosis factor-alpha (TNF-a) inhibitors — which block a type of immune protein in the body — was found to ease signs of inflammation and reduce the need for corticosteroids in people with cardiac sarcoidosis in a new analysis. Safety data, meanwhile, indicated that such treatments were…
Most cardiac sarcoidosis patients respond to six months of first-line treatment with the corticosteroid prednisolone and show reduced active inflammation in the heart, according to a small study in Japan. Cardiovascular events were less common among responders relative to those who respondly poorly, further confirming first-line prednisolone’s effectiveness…
Top-line data from an ongoing Phase 2 trial testing Kinevant Sciences’ experimental therapy namilumab in adults with pulmonary sarcoidosis are expected in the second half of 2024. That’s according to a business update from Roivant Sciences, the parent company to Kinevant. Called RESOLVE-Lung (NCT05314517), the…
MRI scans of the heart may help in predicting the risk of cardiac sarcoidosis recurring after initial successful treatment, a study reports. A greater extent of scarred heart tissue prior to treatment, in particular, was associated with a five times higher risk of relapse. The presence of sarcoidosis only…
Death rates while waiting for a lung transplant are disproportionally higher among people with pulmonary sarcoidosis than for those with other lung disorders, a U.S. study shows. “Our research shows that further consideration needs to be given to how we classify patients with sarcoidosis and how we calculate their…
The Foundation for Sarcoidosis Research (FSR) is funding a new research project that aims to find biological markers that could help identify people with sarcoidosis who are at risk of developing advanced lung disease. The work will be led by Christen Vagts, MD, an early career physician scientist…
The U.S. Food and Drug Administration (FDA) has greenlit a month-old request by Molecure to begin a Phase 2 clinical trial of its investigational oral therapy OATD-01 in people with pulmonary sarcoidosis. The proof-of-concept study, which is ready to launch, according to Molecure, will be the first…
Patterns of multiorgan involvement in African Americans with sarcoidosis differ from those of Americans of European ancestry, a study suggests. But in both groups, certain genetic mutations are associated with specific patterns of organ involvement. Collectively, its findings “support ancestry-specific differences likely resulting from distinct social, cultural, and environmental…
Cardiac sarcoidosis affects slightly more women, but men with the disease are at higher risk of potentially fatal heart rhythm abnormalities, according to a study in Japan. The findings suggest more aggressive preventive treatment for heart problems may be warranted for men with cardiac sarcoidosis, the researchers noted in “…
Meitheal Pharmaceuticals has entered into an agreement with Xentria to market XTMAB-16, the investigational treatment for pulmonary sarcoidosis, should it be approved in the future. Under the terms of the agreement, Meitheal gains the sole rights to sell and distribute XTMAB-16 in North America. Xentria retains the…
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